Biotechnology: Products of Secondary Metabolism, Volume 7, Second Edition

Products of secondary metabolism from fermentation and cell culture are mainly pharmaceuticals, ranging from traditional antibacterials like beta-lactams, new generation compounds like dalbaheptides and lantibiotics to immunomodulators and antitumor drugs. The major fields of application of these low volume/high price products are human and veterinary medicine as well as plant protection. In this volume functionally based screening approaches and the applications of molecular genetics in the discovery and process improvement of compounds are emphasized. Along with the exploitation of new sources the growing understanding of biosynthetic processes permits the identification of the genetic backgrounds.
Topics included are: Novel Receptor-Active Compounds - Microbial Lipids - Microbial Siderophores - beta-Lactam Antibiotics - Peptide Antibiotics - Lantibiotics - Glycopeptide Antibiotics (Dalbaheptides) - Aminoglycosides - Products from Basidiomycetes - Cyclosporins - Secondary Products from Plant Cells - Antitumor Agents
Content:
Chapter 1 General Aspects of Secondary Metabolism (pages 1–55): Hans von Dohren and Udo Grafe
Chapter 2 Regulation of Bacterial Antibiotic Production (pages 57–105): Keith F. Chater and Mervyn J. Bibb
Chapter 3 Screening of Novel Receptor?Active Compounds of Microbial Origin (pages 107–132): Haruo Tanaka and Satoshi Omura
Chapter 4 Microbial Lipids (pages 133–197): Colin Ratledge
Chapter 5 Microbial Siderophores (pages 199–246): Gunther Winkelmann and Hartmut Drechsel
Chapter 6 Advances in the Molecular Genetics of ??Lactam Antibiotic Biosynthesis (pages 247–276): Paul L. Skatrud, Torsten Schwecke, Henk Van Liempt and Matthew B. Tobin
Chapter 7 Peptide Antibiotics (pages 277–322): Horst Kleinkauf and Hans von Dohren
Chapter 8 Lantibiotics (pages 323–368): Ralph Jack, Friedrich Gotz and Gunther Jung
Chapter 9 Glycopeptide Antibiotics (Dalbaheptides) (pages 369–396): Giancarlo Lancini and Bruno Cavalleri
Chapter 10 Aminoglycosides and Sugar Components in